ea0037gp.24.07 | Thyroid–genetics | ECE2015
Pilli Tania
, Cantara Silvia
, Busonero Giulia
, Cardinale Sandro
, Cevenini Gabriele
, Sebastiani Guido
, Dotta Francesco
, Pacini Furio
Background: MicroRNAs (miRNAs) are small non-protein encoding RNAs which negatively regulate gene expression. Tissue miRNA profiles may be useful to distinguish benign from malignant lesions. Recently, we have identified in the serum of a retrospective series of patients, with benign nodular goiter (n=80) and papillary thyroid cancer (PTC: n=79), two miRNAs (-190 and -95) that in combination (providing the risk of malignancy defined as pmiRNA) allow the diffe...